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KMID : 0387420200310040301
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Korean Society of Oriental Neuropsychiatry
2020 Volume.31 No. 4 p.301 ~ p.314
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A Study on the Combination Effect of Herbal Medicine and Western Medicine on BPSD in Patients with Alzheimer’s Disease: A Systematic Review
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Kim Man-Gi
Chang Seok-Joo
Chang Seok-Joo
Hong Min-Ho
Kim Geun-Woo
Koo Byung-Soo
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Abstract
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Objectives: The purpose of this study was to provide clinical evidence to support the use of herbal medicine combined with western medicine for BPSD.
Methods: Studies were identified by searching CNKI, Pubmed, EMBASE, Cochrane Library, SCIENCEON, RISS, KMbase, KISS, OASIS. Literature searches of Chinese, English, and Korean databases were performed.
Two authors independently extracted the data and evaluated the quality of each study.
Results: The literature search identified 203 articles. Of these, 7 were selected for the analysis. The risk of bias in most studies was unclear. The most frequently used diagnostic tools were the NINCDSADRDA and DSM-Ⅳ. The most commonly used results indicator was NPI. In 6 of the 7 papers, combination treatment (herbal & Western medicine) was statistically significantly more effective than single treatment (Western medicine alone) for BPSD. No significant adverse events were reported.
Conclusions: Herbal medicine in combination with Western medicine is more effective for treating BPSD than Western medicine alone. However, the quality of the studies used in this study was uncertain and the sample size was too small. Based on the findings of this study, more high-quality clinical trials are needed to confirm the efficacy of combination treatment.
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KEYWORD
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BPSD, Behavioral and Psychological Symptoms of Dementia, Herbal medicine, Combined therapy
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